Research advances in influencing factors for the antiviral effect of nucleos(t)ide analogues
10.3969/j.issn.1001-5256.2017.07.032
- VernacularTitle:核苷和核苷酸类药物抗HBV疗效的影响因素研究进展
- Author:
Lili WANG
;
Yuedong LIANG
- Keywords:
hepatatiis B virus;
nucleosides;
nucleotides;
review
- From:
Journal of Clinical Hepatology
2017;33(7):1349-1353
- CountryChina
- Language:Chinese
-
Abstract:
Nucleos(t)ide analogues (NAs) have been widely used in clinical practice as first-line antiviral drugs.In recent years, many clinical studies have found that some patients cannot reach a satisfactory therapeutic outcome.This article introduces the antiviral indications and follow-up of chronic hepatitis B and summarizes the influence of baseline characteristics, HBV genotype, HBV mutation and drug resistance, patients'' medication compliance, presence or absence of other diseases or viral infection, and serum vitamin D level on the antiviral effect of NAs.It is pointed out that appropriate timing for antiviral therapy, patient education before treatment, regular follow-up during treatment, and timely identification of comorbidities and drug resistance help to improve the antiviral effect of NAs and delay the progression of liver diseases.
