Influence of maintained hemodialysis on viral load in patients with end-stage renal disease with HBV infection
10.3969/j.issn.1001-5256.2017.07.033
- VernacularTitle:维持性血液透析对终末期肾病合并HBV感染者病毒载量的影响
- Author:
Huifang ZHANG
;
Yongguo LI
- Keywords:
hemodiafiltration;
end-stage renal disease;
hepatitis B virus;
viral load;
review
- From:
Journal of Clinical Hepatology
2017;33(7):1354-1357
- CountryChina
- Language:Chinese
-
Abstract:
In the patients with end-stage renal disease (ESRD) with hepatitis B virus (HBV) infection who underwent hemodialysis, the viral load of HBV DNA is relatively low and stable.For this phenomenon, some studies suggest that hemodialysis can reduce the HBV DNA load.The mechanism, which remains unclear, may be as follows: when HBV DNA enters the dialysate through the dialysis membrane, it was adsorbed onto the dialysis membrane;some virus particles were destroyed, and antiviral substances were produced in the course of hemodialysis.At present, there is no consensus on the mechanism responsible for the influence of maintained hemodialysis on the viral load of HBV DNA.This article reviews the factors involved in the influence of maintained hemodialysis on the viral load in ESRD patients with HBV infection and the recent progress.
