Advances in the application of GPC3 in treatment of liver cancer
10.3969/j.issn.1001-5256.2017.07.037
- VernacularTitle:磷脂酰肌醇蛋白聚糖3在肝癌治疗中的应用进展
- Author:
Zhizhong REN
;
Yuewei ZHANG
- Keywords:
liver neoplasms;
glypicans;
therapy;
review
- From:
Journal of Clinical Hepatology
2017;33(7):1369-1372
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer is one of the most common malignant tumors in the world, and traditional liver cancer treatment methods have their own limitations.Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan and is involved in the regulation of individual development and cell proliferation and differentiation.It is also a hepatoma-specific carcinoembryonic antigen.The mechanism of action of GPC3 in the development and progression of liver cancer has become a hot research topic.GPC3 not only has a unique value in the diagnosis of liver cancer, but also plays an important role in the treatment of liver cancer.This article also introduces the application of GPC3-derived tumor vaccines, GPC3 antibodies, GPC3 gene therapy, and targeted therapy and brings new ideas for the treatment of liver cancer.
