Role of cell apoptosis regulated by P53 in treatment of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2017.07.038
- VernacularTitle:P53调控细胞凋亡在肝细胞癌治疗中的作用
- Author:
Si GAO
;
Xiangxuan ZHAO
;
Zaiming LU
- Keywords:
carcinoma,hepatocellular;
genes,p53;
apoptosis;
therapy;
review
- From:
Journal of Clinical Hepatology
2017;33(7):1373-1376
- CountryChina
- Language:Chinese
-
Abstract:
P53 abnormality or mutation is commonly seen in patients with hepatocellular carcinoma (HCC), and therefore, restoration of P53 function has become a research hotspot in the treatment of HCC.This article reviews the association of P53 with Bcl-2 protein family, microRNA, TGFβ, HBV, HCV, and AKT and the role of P53 in regulating cell apoptosis, in order to provide clues for improving the therapeutic outcome of HCC.
