Mechanism of anti-tumor effect of dihydroartemisinin
10.3760/cma.j.issn.1673-422X.2017.06.012
- VernacularTitle:双氢青蒿素的抗肿瘤作用机制
- Author:
Wenmiao PENG
;
Hongxing FU
;
Lifang YU
;
Zhiguo RAO
- Keywords:
Artemisinins;
Neoplasms;
Apoptosis;
Cell proliferation;
Dihydroartemisinin
- From:
Journal of International Oncology
2017;44(6):448-451
- CountryChina
- Language:Chinese
-
Abstract:
Dihydroartemisinin (DHA),the major active metabolite of artemisinin,participates in tumor progression through the following ways:forming free radicals to induce cancer cells death dependent on iron,inducing apoptosis,inhibiting angiogenesis,tumor cells invasion and metastasis,modulating muhidrug resistance,controlling intracellular Ca2+ concentration,regulating cell cycles,cell autophagy and the immune system and so on.Generally,it is considered to be a potential anti-tumor drug.
