Progress of ALK gene inhibitors in the treatment of brain metastases from non-small cell lung cancer

VernacularTitle:ALK基因抑制剂治疗非小细胞肺癌脑转移的研究进展
Author: Wenyu SUN ; Pengfei YAN ; Yingli YUAN ; Kewei MA
Keywords: Carcinoma,non-small-cell lung; Neoplasm metastasis; Anaplastic lymphoma kinase fusion gene inhibitors
From: Journal of International Oncology 2017;44(6):472-475
CountryChina
Language:Chinese
Abstract: Anaplastic lymphoma kinase (ALK) rearrangement is one of the most potent carcinogenic genes in non-small cell lung cancer (NSCLC).The first-generation ALK inhibitor such as crizotinib is superior to chemotherapy for NSCLC patients with ALK rearrangement.At the same time,more and more studies have reported ALK inhibitors in brain metastases of NSCLC patients with intracranial efficiency.However,despite the initial clinical data of first-generation ALK inhibitors in the treatment of ALK-positive NSCLC with brain metastases,different degrees of recurrence of tumors after acquired resistance have posed new challenges for follow-up treatment of cancer patients.A new generation of ALK inhibitors,such as alectinib;ceritinib,AP26113 and PF-06463922 have emerged to solve this problem.