Research progress of glucocorticoid receptor in urological malignant tumors
10.3760/cma.j.issn.1673-422X.2017.06.019
- VernacularTitle:糖皮质激素受体在泌尿系统恶性肿瘤中的研究进展
- Author:
Qidong ZHOU
;
Guangliang JIANG
;
Ke XU
- Keywords:
Receptors,glucocorticoid;
Kidney neoplasms;
Urinary bladder neoplasms;
Prostatic neoplasms
- From:
Journal of International Oncology
2017;44(6):476-479
- CountryChina
- Language:Chinese
-
Abstract:
Glucocorticoid receptor (GR),a member of the steroid receptor superfamily,can mediate the signal pathway of ligands like glucocorticoids,regulate the transcription of target genes,and exert biological activity.GR is expressed in different degrees in three major kinds of urological malignant tumors including renal cancer,bladder cancer and prostate cancer.It also affects the metabolism of tumor cells,and is closely related to the occurrence,development and prognosis of tumors.GR provides an important clue for targeted therapy and endocrine therapy of urological malignant tumors.
