Effect of aerobics exercise on myocardial fibrosis after acute myocardial infarction in rat
10.3760/cma.j.issn.1008-1372.2017.06.015
- VernacularTitle:有氧运动对大鼠急性心肌梗死后心肌纤维化的影响
- Author:
Daliang ZHOU
;
Dan HAO
;
Lin WEI
;
Tianshu ZHANG
;
Weimin LI
;
Xin ZHANG
;
Lifang YU
- Keywords:
Exercise;
Myocardial infarction/CO;
Endomyocardial fibrosis/CO
- From:
Journal of Chinese Physician
2017;19(6):852-854
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of aerobics exercise on myocardial fibrosis after acute myocardial infarction (AMI) in rat.Methods Twenty-four AMI Sprague Dawley (SD) rats were randomly assigned to sham-operated group (Sham),AMI group and aerobics exercise treatment group (ET).Except Sham,other groups of rats were underwent anterior wall myocardial infarction.After ten weeks,the myocardial mRNA level of connective tissue growth factor (CTGF),collagen Ⅰ (COL1 a1),collagen Ⅲ (COL3a1) detected by real time-quantitative polymerase chain reaction (PCR) analysis and myocardial collagen volume fraction (CVF) was determined on Masson stained sections.Results Campared to Sham-operated group,AMI group the level of CTGF,COL1a1,COL3a1,and CVF were increased (P ＜0.05,P ＜ 0.01).Campared to AMI and ET groups,the levels of CTGF,COL1a1,COL3a1,and CVF were decreased (P ＜ 0.05,P ＜ 0.01).Conclusions Aerobics exercise can reduced the myocardial fibrosis after AMI in rat.
