Research of tumor progression locus 2 in tumorigenesis and progression
10.3760/cma.j.issn.1008-1372.2017.06.049
- VernacularTitle:Tpl2在肿瘤发生发展中的研究进展
- Author:
Jinglin LI
;
Wangyang ZHENG
;
Xinheng LI
;
Zhenglong LI
;
Zhidong WANG
;
Xingming JIANG
;
Yunfu CUI
- Keywords:
Mitogen-activated protein kinase kinases;
Neoplasms;
Review
- From:
Journal of Chinese Physician
2017;19(6):946-949
- CountryChina
- Language:Chinese
-
Abstract:
Tumor progression locus 2 (Tpl2) is a crucial three-stage kinase of the mitogen-activited protein kinase (MAPK) family,which plays an important role in MAPK pathway and other signaling pathways.In recent years,a large number of studies have found that aberrant expressing Tpl2 is involved in tumorigenesis and development of various cancers,and is expected to serve as a new biomarker and therapeutic target.Therefore,to reveal the mechanism of Tpl2 will provide a feasible theoretical basis and potential interventional target for the diagnosis and treatment of cancers.
