Research progress on Smad3 protein in hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2017.06.020
- VernacularTitle:Smad3蛋白在肝细胞癌中的作用
- Author:
Zhufeng LU
;
Jinlong HUANG
;
Wei GAN
;
Yong YI
;
Shuangjian QIU
- Keywords:
Transport protein,Smad3;
Transforming growth factor β(TGF-β);
Activin;
Signal pathway;
Hepatocellular carcinoma
- From:
Chinese Journal of Hepatobiliary Surgery
2017;23(6):430-432
- CountryChina
- Language:Chinese
-
Abstract:
Smad3 is a major transporter in the transforming growth factor β (TGF-β) signaling pathway.It is in charge of the transfer of TGF-β signal from the surface of the cell membrane into the nucleus.The TGF-β signal can be bound to the target gene in the nucleus and regulate its expression.Abnormalities in Smad3 expression level and functional status will lead to abnormal signal transduction,involving cell growth,proliferation,development,differentiation,migration,apoptosis and other basic life activities.This review focused on the differential expression of Smad3 in hepatocellular carcinoma (HCC)and the adjacent tissue.The character of Smad3 in HCC is outlined in three parts:Smad3 upstream signaling source,Smad3 self-assembly maturation and Smad3 downstream effects,which may provide a summary and reference for the follow-up study on Smad3.
