Research progresses of vitamin D and aquaporins
10.3760/cma.j.issn.1673-4408.2017.06.006
- VernacularTitle:维生素D与水通道蛋白的研究进展
- Author:
Yu FU
;
Yalin ZHANG
;
Ning LIU
- Keywords:
Vitamin D;
Vitamin D receptor;
Aquaporin;
Chronic kidney disease
- From:
International Journal of Pediatrics
2017;44(6):389-392
- CountryChina
- Language:Chinese
-
Abstract:
Vitamin D is a fat-soluble steroid hormone.Vitamin D receptor(VDR),a type of nuclear receptor,recognized by Vitamin D has many biological functions and the pathway of 1,25 (OH)2D3/VDR plays an important role in human such as regulating calcium phosphate metabolism,glucose metabolism,lipid metabolism and water metabolism.Water channel protein aquaporin(AQP) is a kind of smaller hydrophobic trans-membrahe proteins,expressed in cell membrane of renal tubules,endocrine glands and red blood cells.Aquaporin plays a key role in the regulation of water balance and metabolism.Vitamin D has a positive effect in diabetic nephropathy via inhibiting renin-angiotensin system,while aquaporin is a new biological marker of chronic kidney disease and kidney injury.Latest studies have showed that the expression of aquaporin can be regulated by vitamin D.Therefore,Vitamin D and aquaoprin play an important role in chronic kidney disease and kidney injury.
