Anti-cancer effects of Alternol and Alteronol on human cancers

VernacularTitle:维泰醇和维康醇的抗肿瘤效应
Author: Lihua LIU ; Benyi LI
Keywords: Neoplasms; Apoptosis; Cell cycle; Alternol; Alteronol
From: Journal of International Oncology 2017;44(6):452-455
CountryChina
Language:Chinese
Abstract: Alternol and Alteronol are two small chemical compounds purified from a mutant fungal.The in vitro and in vivo experimental studies have confirmed their potent anti-cancer effect.In vitro studies show that they can inhibit cell division and proliferation of a variety of tumors including prostate cancer,osteosarcoma and melanoma.They exert their anti-cancer effects by attenuating cell cycle protein expression and causing cell cycle arrest,suppressing tumor cell invasion and metastasis,reducing new blood vessel formation,decreasing the expression of anti-apoptotic proteins Bcl-2 in malignant cells,and stimulating oxygen free radical accumulation.However,there is no significant cytotoxic effect on benign cells.Animal experiments show that these two compounds significantly inhibit xenograft growth derived from a variety of human malignant tumors,while there is no obvious side effect on normal tissue or organs.In conclusion,these two compounds are worthy to be developed as novel anti-cancer drugs.