Research advances of cancer therapy targeting HIF-1α-VEGF-VEGFR-2 signaling pathway for malignant tumors
10.3760/cma.j.issn.1673-422X.2017.06.014
- VernacularTitle:靶向调控HIF-1α-VEGF-VEGFR-2通路治疗恶性肿瘤的新进展
- Author:
Fei SUN
;
Jianlin WANG
;
Jingping YU
- Keywords:
Neoplasms;
Neovascularization,pathologic;
Vascular endothelial growth factors;
Receptors,vascular endothelial growth factor;
Signal transduction
- From:
Journal of International Oncology
2017;44(6):456-459
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia inducible factor-1α (HIF-1α)-vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor-2 (VEGFR-2) signaling pathway plays a vital role in the regulation of neovascularization,and the activation of this pathway is closely related with tumor invasion and metastasis.
