Clinical research of renal transplant from donation after citizen's death (DCD) donor with acute kidney injury
10.3760/cma.j.issn.0254-1785.2017.03.002
- VernacularTitle:急性肾损伤供肾用于肾移植的临床研究
- Author:
Heli XIANG
;
Wujun XUE
;
Puxun TIAN
;
Xiaoming DING
;
Xiaoming PAN
;
Hang YAN
;
Jun HOU
;
Xinshun FENG
- Keywords:
Acute kidney injury;
Organ donation;
Kidney transplantation
- From:
Chinese Journal of Organ Transplantation
2017;38(3):131-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of renal transplant from donation after citizen's death (DCD) donors with acute kidney injury (AKI).Methods This was an observational retrospective study of 622 patients who underwent renal transplantation from 312 DCD donors' kidneys at the First Affiliated Hospital of Xi'an Jiaotong University from December 2011 to December 2016.The transplant patients were divided into AKI group and non-AKI group according to the Acute Kidney Injury Network (AKIN) criteria based on initial and terminal creatinine values.We evaluated and compared transplant outcomes of these two groups.Results There were 131 donors with AKI,and the incidence of AKI was 42.0 ％.AKI group and non-AKI group recipients respectively had DGF in 20.2％ and 7.2％ of cases (P＜0.01),153.6 ± 56.2 and 119.3 ± 40.7 μmol/L of serum creatinine (SCr) levels at 1st month (P＜0.01),and 38.5 ± 14.1 and 57.6 ± 23.4 ml· min-1 (1.73 m2)-1 of eGFR at 1st month (P＜0.01).There was no significant difference in SCr and eGFR between two groups at 1st year after transplantation.Conclusion Most of kidneys from DCD donors with AKI can be considered for transplantation.Renal transplantation of organs from DCD donors with AKI showed greater DGF but good outcomes.
