Renal transplant from donors with primary central nervous system tumors: single center experience

Qian Huang; Xinqiang Wang; Jipin Jiang; Sheng Chang; Lan Zhu; Dunfeng DU; Bin Liu; Xia LU; Nianqiao Gong; Zhengbin Lin; Gang Chen; Fanjun Zeng; Changsheng Ming; Ping Zhou; Zhishui Chen; Weijie Zhang

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Renal transplant from donors with primary central nervous system tumors: single center experience

VernacularTitle:原发性中枢神经系统肿瘤供者供肾移植63例安全性分析
Author: Qian HUANG ; Xinqiang WANG ; Jipin JIANG ; Sheng CHANG ; Lan ZHU ; Dunfeng DU ; Bin LIU ; Xia LU ; Nianqiao GONG ; Zhengbin LIN ; Gang CHEN ; Fanjun ZENG ; Changsheng MING ; Ping ZHOU ; Zhishui CHEN ; Weijie ZHANG
Keywords: Kidney transplant; Central nervous system neoplasms,primary; Donor selection; Neoplasm metastasis
From: Chinese Journal of Organ Transplantation 2017;38(3):136-140
CountryChina
Language:Chinese
Abstract: Objective To analyze the safety of renal transplant from donors with primary central nervous system (CNS) tumors.Methods We retrospectively analyzed the clinical data of 33 donors with primary CNS tumors and the 63 corresponding renal recipients between January 2013 and December 2016 in Tongji Hospital.Results The mean period from diagnosis as primary CNS tumor to donation was about (21.8± 46.4) months (range:0.5 to 192.0 months).The pathological classification of these tumors included gliomas,meningioma,medulloblastoma,etc.Besides,there were 10 donors with high-grade CNS malignancies.Eleven donors have ever been through at least one of the four treatments (craniotomy,V-P/V-A shunt,radiotherapy and chemotherapy),14 donors have undergone none,and the clinical data of rest were unavailable.All the 63 recipients got well renal function after transplant.During an average follow-up of (15.9 ± 8.2) months (range:2.7 to 35.5 months),one recipient got donor-derived rhabdoid tumor 4 months posttransplant,underwent comprehensive treatments,including allograft nephrectomy,radiotherapy,chemotherpy and returned to hemodialysis,while the 62 cases got no donor-derived tumors.Conclusion Tumor transmission of renal allograft from donors with primary CNS tumors is inevitable but with low risk,which means this kind of donors can be used with careful assessment,full informed consent and good balance between wait-list death and tumor transmission.