Clinical analysis of mechanical perfusion in donor after cardiac death kidney transplantation
10.3760/cma.j.issn.0254-1785.2017.03.006
- VernacularTitle:低温机械灌注在器官捐献供肾移植中的临床效果分析
- Author:
Zhenpu WANG
;
Dong SUN
;
Xin JIANG
;
Dongfeng GU
;
Qingshan QU
- Keywords:
Kidney transplantation;
Mechanical perfusion;
Cryopreservation;
Kidney fuction;
Organ donation
- From:
Chinese Journal of Organ Transplantation
2017;38(3):149-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of mechanical perfusion preservation kidney transplantation in donor after cardiac death (DCD),and to explore the effect of mechanical perfusion preservation of DCD on renal function recovery.Methods The clinical data of 186 patients undergoing DCD kidney transplantation from January 2012 to December 2016 were retrospectively analyzed.Sixty-eight DCD donor's kidneys were preserved by LifePortpreservation (low temperature mechanical perfusion group),118 DCD donor's kidneys were preserved by static low temperature preservation (static low temperature preservation group).The renal function recovery,the incidence of primary non-function,delayed graft function and infection,and the survival rate of patients and renal grafts were analyzed.Results There was no significant difference between the two groups in gender,age,hemodialysis ratio,dialysis time,BMI,warm ischemia time and cold ischemia time (P＞0.05).There was significant difference in creatinine value between the two groups at 1st week (P＜0.05),but there was no significant difference in creatinine at 3rd,6th,12th,24th and 36th month (P＞0.05).There was significant difference in the incidence of DGF between two groups (P＜0.05),but no significant difference in the incidence rate of PNF,AR and infection,and the survival rate of patient and renal graft between two groups (P＞0.05).There was no significant difference in 1-and 3-year survival rate of the recipients and transplanted kidney between the two groups (P＞0.05).Conclusion LifePort can significantly reduce the incidence of DGF as compared with static cold preservation.The resistance index and perfusion flow of the LifePort have important significance to assess the renal quality.
