Effects of DDX family on cancer development and progression
10.3760/cma.j.issn.1673-4203.2017.05.019
- VernacularTitle:DDX家族与肿瘤的相关性研究进展
- Author:
Yeqian ZHANG
;
Hui CAO
- Keywords:
DEAD-box protein;
DEAD-box RNA helicases;
Neoplasms;
Review
- From:
International Journal of Surgery
2017;44(5):350-353,封4
- CountryChina
- Language:Chinese
-
Abstract:
DEAD box family,characterized by the conserved motif D (Asp)-E (Glu)-A (Ala)-D (Asp),are putative RNA helicases,which participate in all cellular processes regulated by RNAs.Studies show that there are examples of dysregulation of DDX family expression in various types of cancer.They are involved in the occurrence and evolution of tumor,and take part in tumor cell proliferation,apoptosis,cycle,invasion,metastasis and metabolism,which can be acted as new molecular markers for the diagnosis of tumor,the evaluation of malignancy and the prediction of clinical prognosis and also provide new potential molecular targets for tumor therapy.Here,we reviewed the structure,biochemical function and the relationship with tumor of DDX family.
