Chemotherapy and tumor immunogenic cell death
10.3760/cma.j.issn.1673-422X.2017.05.011
- VernacularTitle:化疗与肿瘤免疫原性细胞死亡
- Author:
Cong LUO
;
Ning TAO
- Keywords:
Drug therapy;
T-cell antigen receptor specificity;
Dendritic cells;
Calreticulin;
Immunogenic cell death
- From:
Journal of International Oncology
2017;44(5):369-372
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy resist is the problem for clinic,and some researches find that chemotherapy with anthracycline and oxaliplatin not only induces the tumor cell apoptosis,but also the celt immunogenic cell death (ICD) by inducing the tumor cell apoptosis and releasing three kinds of signals:exposure of calreticulin on the cell surface to stimulate the dendritic cell (DC) to engulf,and the secretion of adenosine triphosphate to recruit DC to enter into tumor bed,and the release of the high mobility group B1 to promote DC to steadily bind with dying tumor cell to induce specific T cell antitumor immune response.It is with great meaning to promote the chemotherapy protocol by studying the ICD induced by chemotherapy.
