Relationship between levels of miR-125b and miR-181c in cerebrospinal fluid before joint replacement and postoperative delirium in elderly patients
10.3760/cma.j.issn.0254-1416.2017.05.011
- VernacularTitle:老年患者关节置换术前脑脊液miR-125b及miR-181c水平与术后谵妄的关系
- Author:
Rui DONG
;
Lingling SUN
;
Xin XU
;
Xi YANG
;
Zongze ZHANG
;
Yanlin WANG
;
Mian PENG
- Keywords:
MicroRNAs;
Delirium;
Aged;
Risk factors
- From:
Chinese Journal of Anesthesiology
2017;37(5):551-554
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the levels of microRNA-125b (miR-125b) and miR-181c in cerebrospinal flnid (CSF) before joint replacement and postoperative delirium (POD) in elderly patients.Methods Fifty-two patients of hoth sexes,aged ≥ 65 yr,weighing 45-70 kg,of American Society of Anesthesiologists physical status Ⅰ-Ⅲ,scheduled for elcctive hip or knee replacement under spinal anesthesia,were included in the study.CSF was collected after successful puncture to measure the levels of miR-181c and miR-125b by fluorescent quantitative real-time polymerase chain reaction.The patients were divided into POD group and non-POD group using the Chinese reversion of Confusion Assessment Method on postoperative days 1 and 2.Results The incidence of POD was about 28％ in the patients underwent hip or knee replacement.Compared with non-POD group,the preoperative level of miR-181c in CSF was significantly increased (P＜0.05),and no significant change was found in the preoperative level of miR-125b in CSF in POD group (P＞0.05).Conclusion The level of miR-181c in CSF before joint replacement is related to POD in elderly patients,and the preoperative level of miR-181c in CSF is a risk factor for POD.
