Correlation between peak intensity of contrast enhanced ultrasound and injury severity after liver ischemia reperfusion

VernacularTitle:大鼠肝缺血再灌注后超声造影峰值强度与肝脏损伤程度之间的关系
Author: Hong LI ; Ying CHENG ; Lei YANG ; Yunfei ZHANG
Keywords: contrast enhanced ultrasound; liver; ischemia reperfusion; ALT; AST; pathology
From: Chinese Journal of Organ Transplantation 2017;38(4):234-238
CountryChina
Language:Chinese
Abstract: Objective To discuss the correlation between peak intensity (PI) of contrast enhanced ultrasound and injury severity after liver ischemia reperfusion.Methods Pringle's maneuver was used to establish the liver 15-min ischemia model.Contrast enhanced ultrasound was used to observe the hepatic perfusion after reperfusion of 1 h,6 h and 24 h,and the PI was recorded.The correlation analysis on PI with alanine aminotransferase (ALT),aspartate aminotransferase (AST) and pathologic changes (Suzuki standard) was done.Results PI decreased after 1 h,6 h,and 24 h of liver reperfusion,most significantly at 6 h.ALT reached the peak after 1 h of reperfusion and then decreased after 6 h and 24 h.AST increased after 6 h of reperfusion and decreased after 24 h.After 1 h of reperfusion,mild injury appeared in pathology and the injury became severe after 6 h,then it got moderate-to-severe after 24 h of reperfusion.PI was negatively correlated to ALT,AST and pathologic injury degree.Conclusion The PI relates to the degree of hepatic injury after liver ischemia/reperfusion.The more severe the injury is,the lower the PI.