Core needle biopsy for molecular classification of breast cancer
10.3760/cma.j.issn.1007-631X.2017.01.016
- VernacularTitle:空心针穿刺活检对确定乳腺癌分子亚型的诊断价值
- Author:
Sheng CHEN
;
Ye WANG
;
Weiwei LIU
;
Huaitao WANG
;
Shujuan JIN
;
Xiaowei HAN
;
Yan HUANG
- Keywords:
Breast neoplasms;
Biopsy,needle;
Molecular typing;
Ki-67 antigen
- From:
Chinese Journal of General Surgery
2017;32(1):49-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate core needle biopsy (CNB) in detecting estrogen receptor (ER) and progesterone receptor (PR) of HER2,Ki67,and molecular classification of breast cancer.Methods Clinical data of 188 breast cancer patients admitted from Nov 2012 to Jun 2015,were retrospectively analyzed.All patients received both CNB and open excision biopsy (OEB).Immunohistochemistry (IHC) was used to evaluate the expression of ER,PR,HER2 and Ki67.All cases were categorized into four molecular subtypes:Luminal A,Luminal B,triple negative breast canccr and HER2 over-expression breast cancer.Kappa test was used to evaluate the consistency of CNB and OEB.Results Concordance rate of ER,PR,HER2 receptor status and Ki67 value were 94.68％,93.62％,94.68％ and 73.40％.There was no difference between CNB and OEB for non-Luminal tumors (P =0.774).Ki67 expression in OEB samples was higher than in CNB samples (25.90％ vs.21.65％,P ＜ 0.001).Concordance rate between CNB and OEB for molecular subtypes was 72.34％ (K =0.606 4).Conclusions CNB is accurate in evaluating ER,PR,HER2 and Ki67 in breast cancer.CNB is accurate in diagnosing non-Luminal molecular subtypes of breast cancer.
