Study on the in vitro Transdermal Absorption Properties of Galangin
10.6039/j.issn.1001-0408.2017.19.11
- VernacularTitle:高良姜素的体外透皮吸收特性研究
- Author:
Shixia HUO
;
Li GAO
;
Xiaoming PENG
;
Jixuan WEN
;
Ming YAN
- Keywords:
Galangin;
Transdermal absorption;
Transdermal enhancer;
Complete skin;
Exfoliating skin;
Dermis skin
- From:
China Pharmacy
2017;28(19):2631-2634
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the in vitro transdermal absorption properties of galangin and effects of different pene-tration enhancers on its transdermal behaviors,and provide reference for developing skin preparations using galangin as APIs in the treatment of vitiligo. METHODS:HPLC was used to determine the galangin content. Using cumulative permeation rate (Q) and the transdermal rate(J)of galangin as indexes,the effect of absorption of receiving solution [20%,40% polyethylene glycol 400 (PEG400)solution and 30% ethanol solution] and rotating rate(200,300,400 r/min)on galangin in complete skin of mice were investigated,as well as the azone(1%,3%,5%)and propylene glycol(10%,20%,40%)alone or combination on its penetra-tion promotion. And the transdermal properties of galangin in complete skin,exfoliating skin,dermis skin of rats and mice were de-tected. RESULTS:The best permeability of complete skin of mice showed in 40% PEG400 solution at rotating speed of 300 r/min with 5% azone alone,J was 3.2570 μg/(cm2·h). Js of complete skin,exfoliating skin,dermis skin of mice were 2.7199,34.016, 33.874 μg/(cm2·h),respectively;and those of rats were 0.4996,9.5124,17.406 μg/(cm2·h). CONCLUSIONS:Galangin can penetrate the complete skin of mice and rats,however,the penetration quantity is far lower than exfoliating skin and dermis skin.
