Study on the Alleviation Effect and Its Mechanism of Nervonic Acid on Movement Disorder of Model Mice with Parkinson's Disease
10.6039/j.issn.1001-0408.2017.19.16
- VernacularTitle:神经酸对帕金森病模型小鼠运动障碍的缓解作用及机制研究
- Author:
Hui ZHENG
;
Zuoqian SUN
;
Zhiliang WANG
;
Zhengfeng WEI
;
Yan FENG
;
Xingzhu ZHANG
;
Fucang WANG
;
Yongqiang SHI
;
Zhaolin GAO
- Keywords:
Nervonic acid;
Parkinson's disease;
Mice;
Movement disorder;
Dopamine
- From:
China Pharmacy
2017;28(19):2648-2651
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the alleviation effect of nervonic acid on movement disorder of model mice with Parkinson's disease(PD). METHODS:Mice were randomly divided into blank control group(normal suline),model group(normal saline), Levodopa and benserazide hydrochloride tablet group (positive control,calculated by L-dopamine 120 mg/kg),nervonic acid low-dose,medium-dose,high-dose groups(20.0,40.0,80.0 mg/kg),10 in each group. Except for blank control group,mice in other groups were inducced for PD models. After modeling,mice were intragastrically given relevant medicines,once a day,for 14 d. After the last administration,behavioral changes of mice in each group were observed. HPLC was conducted to detect dopa-mine(DA)and its metabolites dihydroxybenzoic acid(DOPAC),homovanillic acid(HVA)concentrations in the striatum of mice. RESULTS:Compared with blank control group,climbing time was extended in model group,drum time was shortened,spontane-ous movement times was decreased,and DA,DOPAC,HVA contents in the striatum were reduced (P<0.05). Compared with model group,climbing time was shortened in Levodopa and benserazide hydrochlo ride tablet group,nervonic acid dose groups, drum time was extended,and DA,DOPAC,HVA contents in the striatum were increased(P<0.05);and spontaneous movement times was increased in Levodopa and benserazide hydrochloride tablet group,and nervonic acid high-dose group(P<0.05). CON-CLUSIONS:Nervonic acid can effectively improve symptoms of movement dysfunction of model mice with PD. The mechanism may associate with increasing DA content in the striatum.
