The Role of Segmental Analysis of Clonazepam in Hair in Drug Facilitated Cases

VernacularTitle:头发中氯硝西泮的分段分析在药物辅助犯罪案件中的作用
Author: Hang CHEN ; Ping XIANG ; Min SHEN
Keywords: forensic toxicology; clonazepam; hair; chem istry; analytic; drug facilitated crim es
From: Journal of Forensic Medicine 2017;33(3):252-257
CountryChina
Language:Chinese
Abstract: Objective T o infer the frequency of dosage and m edication history investigate of the victim s in drug facilitated cases by the segm ental analysis of clonazepam in hair. Methods Freezing m illing un-der liquid nitrogen environm ent com bined w ith ultrasonic bath w as used as sam ple pretreatm ent in this study, and liquid chrom atography-tandem m ass spectrom etry w as used for the segm ental analysis of the hair sam ples collected from 6 victim s in different cases. T he concentrations of clonazepam and 7-am in-oclonazepam w ere detected in each hair section. Results C lonazepam and its m etabolite 7-am inoclon-azepam w ere detected in parts of hair sections from the 6 victim s. T he occurrence tim e of drug peak concentration w as consistent w ith the intake tim ing provided by victim s. Conclusion Segm ental analysis of hair can provide the inform ation of frequency of dosage and intake tim ing, w hich show s an unique evidential value in drug facilitated crim es.