Research Progress of the Relationship between the Expression of TAR DNA-bind-ing Domain Protein 43 and Brain Injury
10.3969/j.issn.1004-5619.2017.03.016
- VernacularTitle:TAR DNA结合蛋白43的表达与脑损伤的相关性研究进展
- Author:
Yao YE
;
Rubo LI
;
Shiyu MA
;
Xueting WEI
;
Qi XU
- Keywords:
forensic pathology;
brain injuries;
review;
T A R D N A-binding dom ain protein 43
- From:
Journal of Forensic Medicine
2017;33(3):289-292
- CountryChina
- Language:Chinese
-
Abstract:
T A R D N A-binding dom ain protein 43 (T D P-43) is a highly conserved and w idely expressed nuclear protein. N ow adays, the expression of T D P-43 can be found in m ost neurodegenerative diseases such as A lzheim er's disease, w hich m akes it becom e a neurodegenerative disease associated m arker pro-tein. From the current research status at hom eland and abroad, and around the relationship betw een the expression of T D P-43 and brain injury, this article em phatically probes into the specific expression and function of T D P-43 in acute and chronic brain injury based on the know ledge of its biological charac-teristics, w hich aim s to explore the feasibility for determ ining the cause of death and the injury and dis-ability situations by T D P-43 in forensic pathology.
