The regulation of TGF-β1 in cardiac death caused by variation of SCN5A gene
10.13618/j.issn.1001-5728.2017.03.015
- VernacularTitle:TGF-β1在SCN5A基因变异所致心源性猝死中调控作用
- Author:
Bo HAO
;
Weiping SONG
;
Fangyu WU
;
Xiaoguang WANG
;
Bin LUO
- Keywords:
forensic pathology;
sudden cardiac death;
gene mutation;
myocardial fibrosis;
iron channel;
SCN5A;
TGF-β1
- From:
Chinese Journal of Forensic Medicine
2017;32(3):290-293
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of sudden cardiac death caused by variation in SCN5A is still unclear. Recently, the converging evidences suggest that the dysfunction of regulation mediated by transforming growth factor-β1 in cardiac fibration and reconstruction of cardiac iron channel could be main reason of SUNDS caused by variation of SCN5A. The resent progress of the mechanism of transforming growth factor-β1 in sudden cardiac death caused by variation of SCN5A gene is reviewed in this paper, hoping to provide reference for the research and practice of sudden cardiac death in forensic medicine.
