Relationship between white blood cell count and nonalcoholic fatty liver disease in an adult population
10.3760/cma.j.issn.1674-0815.2017.03.001
- VernacularTitle:成年体检人群中白细胞计数与非酒精性脂肪肝的关联
- Author:
Kun SONG
;
Haiyan XU
;
Zuolin LU
;
Hongbin SHI
;
Li LIU
;
Qing ZHANG
;
Kaijun NIU
- Keywords:
Leukocytes;
Inflammation;
Nonalcoholic fatty liver disease
- From:
Chinese Journal of Health Management
2017;11(3):201-205
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between white blood cell count (WBC) and the prevalence of simple fatty liver disease (SFL) and nonalcoholic steatohepatitis (NASH). Methods We designed a large scale cross-sectional study in an adult population. Participants were selected from Tianjin Medical University's General Hospital-Health Management Centre. The diagnoses of simple fatty liver disease and nonalcoholic steatohepatitis were based on liver ultrasonography and serum alanine aminotransferase concentration. A total of 37507 subjects (8644 SFL and 2557 NASH) were included in this study. Multiple logistic regression analysis was used to assess whether the quartiles of WBC were associated with the prevalence of simple fatty liver disease and nonalcoholic steatohepatitis. Results After adjusting for potential confounders, the odds ratios (95% confidence interval) of simple fatty liver disease and nonalcoholic steatohepatitis for increasing quartiles of WBC were: simple fatty liver disease, 1.00 (reference), 1.37 (1.24, 1.50), 1.70 (1.55, 1.86) and 2.09 (1.90, 2.29) (P for trend<0.0001);nonalcoholic steatohepatitis, 1.00 (reference), 1.39 (1.16, 1.66), 1.69 (1.43, 1.99) and 2.13 (1.81, 2.50) (P for trend<0.0001). Conclusions This study proves the correlation between WBC and the prevalence of simple fatty liver disease and nonalcoholic steatohepatitis. Further study is needed to clarify whether WBC has a predictive value for the occurrence of nonalcoholic fatty liver disease.
