Expression of matrix metalloproteinase-9 and tension protein homologous gene(PTEN)in gingival carcinoma and its clinical significance
10.3969/j.issn.1005-1678.2017.07.012
- VernacularTitle:基质金属蛋白酶-9及张力蛋白同源基因在牙龈癌中的表达以及临床意义
- Author:
Zhifang DONG
;
Jun JING
;
Yixuan JING
- Keywords:
matrix metalloproteinase;
MMP-9;
tension homolog gene;
PTEN;
gum cancer
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(7):37-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of matrix metalloproteinase(MMP-9)and tension protein homologous gene in gingival cancer tissue.Methods 50 cases in Guyuan people's hospital from June 2013to December 2016 were selected to study the expression of matrix metalloproteinase(MMP-9)and tension protein homologous gene in gingival cancer tissue.Results The positive rate of PTEN in gingival cancer group was 54.00%, the positive rate of PTEN was 94.00% in normal tissue, normal control group positive rate of PTEN was significantly higher than that of gingival cancer group(P<0.05);the positive rate of MMP-9 in gingival cancer group was 76.00%, the positive rate of control group was 20.00%, gingival cancer group was significantly higher than the normal control group(P<0.05).The expression of MMP-9 and PTEN in in gingival cancer tissue was unrealted with gender, age, and tissue differentiation, and associated with lymph node metastasis and tissue infiltration(P<0.05).Conclusion PTEN expression is low in gingival cancer tissue low, MMP-9 expression is high in gingival cancer tissues.PTEN and MMP-9 are closely related to the incidence and development of gingival cancer.Therefore, MMP-9 positivity is a risk factor for gingival cancer, while PTEN positivity is a protective factor for gingival cancer.
