Effect of lyceum barbarum combined with corticosteroids on the treatment of acute anterior uveitis and its impact on related cytokines
10.3969/j.issn.1005-1678.2017.07.058
- VernacularTitle:枸杞联合激素治疗急性前葡萄膜炎的疗效及其对相关细胞因子的影响
- Author:
Wanbao LU
- Keywords:
acute anterior uveitis;
cytokines;
corticoid;
lyceum barbarum
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(7):152-154,156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and compare the effect of lyceum barbarum combined with corticosteroids and corticosteroids alone on the treatment of acute anterior uveitis(AAU), to explore the mechanism of lyceum barbarum could auxiliary treat AAU.Methods 60 cases with AAU were randomly divided into lyceum barbarum combined with corticosteroids treatment group(combination therapy group), simple corticosteroids treatment group(cortisol treatment group) and health control group.Health control group consists of healthy volunteers.Results The efficient rate of the combination therapy group in the early treatment stage(1 week) was 86%, the cortisol treatment group was 62%.In the late stage treatment(2 weeks) the efficient rate was 98% and 80% in the cortisol treatment group.The total efficiency rate in the two groups was significant difference(P<0.05).The level of IL-10、TNF-α、 IFN-γ and IL-23 in the combination therapy group and cortisol treatment group were significantly higher than those in healthy control group in AAU attack period(P<0.01), the levels of these cytokines were significantly decreased after treatment(P<0.01).IL-10 was significantly higher in patients before treatment than that in healthy control group(P<0.01), IL-10 in cortisol treatment group was increased than that before treatment, IL-10 in combination therapy group was decreased after treatment than that before treatment(P<0.05).The level of IFN-γ in the combination therapy group and cortisol treatment group were higher than that in healthy control group after treatment(P<0.05).Conclusion The levels of IFN-γ, IL-10, TNF-α, IL-23 in acute attack stage in AAU patients were significantly higher than those after treatment and other people with physical examination, while the treatment of lyceum barbarum combined with hormone, IFN-γ and IL-23 levels decreased significantly, the effect was obvious, which is worthy of promotion.
