Effects of Minocycline Hydrochloride Ointment on Collagenase in Gingival Crevicular Fluid
10.3969/j.issn.1005-1678.2017.07.083
- VernacularTitle:盐酸米诺四环素软膏对龈沟液中胶原酶的影响
- Author:
Yu JI
;
Xufei YAO
- Keywords:
minocycline hydrochloride ointment;
Gingival crevicular fluid;
collagenase
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(7):211-212,215
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of minocycline hydrochloride ointment on collagenase in gingival crevicular fluid.Methods 60 patients with chronic periodontitis treated in our hospital from January 2015 to December 2016 were selected as the research object, the patients were divided into two groups according to their intervention methods, 30 cases in each group.The control group was treated with ultrasound clean governance and iodine glycerol, the observation group was treated with ultrasound clean governance and minocycline hydrochloride ointment The experimental data of the two groups were compared.Results The index change of gingival crevicular fluid volume plaque index,,depth of exploration and clinical attachment loss in the observation group were better than those in the control group, the difference between the two groups was statistically significant (P<0.05);The clinical therapeutic effect of the observation group(93.3%)was better than that of the control group(73.3%), and the difference between the two groups was statistically significant (P<0.05).The incidence of adverse reactions in the observed group(10.0%)was lower than that in the control group(26.7%), and the difference between the two groups was statistically significant (P<0.05).Conclusion Minocycline hydrochloride ointment can affect the level of collagenase in gingival crevicular fluid, and the clinical effect of the treatment of chronic periodontal disease is significant.
