Progress of Pseudomonas aeruginosa and its biofilm with human innate immune response

VernacularTitle:铜绿假单胞菌及其生物膜与机体固有免疫相互作用研究进展
Author: Sufei WANG ; Wei WEI ; Bing YU ; Ming NI
Keywords: Pseudomonas aeruginosa; Biofilm; Extracellular matrix
From: Chinese Journal of Clinical Infectious Diseases 2017;10(3):236-240
CountryChina
Language:Chinese
Abstract: Pseudomonas aeruginosa (PA) is a kind of opportunistic pathogen which can cause a wide range of serious infections clinically.These infections are often associated with the formation of biofilm, and are difficult to treat due to the complexity of mechanisms.Some studies have showed that genotype and phenotype of biofilm PA will change, and biofilm PA will aggregate together and secrete extracellular polymeric substance.Therefore, innate immune system could not recognize the camouflaged antigens.Besides, biofilm PA can secrete a variety of virulent factors to hamper the function of innate immune system.This article introduces the main chronic infection caused by PA biofilm and the relationship between biofilm PA and natural innate immune system.