Application of ROC curve for evaluating risk evaluation value of serum LDH, BXTM, β2-MG,CRP and DD in bone marrow infiltration of non-Hodgkin's lymphoma
10.3969/j.issn.1671-8348.2017.18.013
- VernacularTitle:应用ROC评价LDH、BXTM、β2-MG、CRP和D-D指标在NHL骨髓浸润中的风险评估价值
- Author:
Yuqing ZHANG
;
Youhui XU
;
Rong CHEN
;
Xuesen ZOU
- Keywords:
non-Hodgkin's lymphoma;
lactate dehydrogenase;
C-reactive protein;
beta 2-microglobulin;
D-dimer;
bo xin serum tumor associated material
- From:
Chongqing Medicine
2017;46(18):2486-2488,2491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the indexes change of lactate dehydrogenase(LDH),serum tumor associated material(BXTM),β2-microglobulin(β2-MG),C-reactive protein(CRP) and D-dimer(DD) with lymphoma cell bone marrow infiltration(BMI) degree in the patients with non-Hodgkin's lymphoma(NHL).Methods Seventy-four cases of initially treated NHL were retrospectively analyzed and divided into the bone marrow invasion group(BMI,26 cases),lymphoma cell leukemia group(LMCL,31 cases) and non-BMI group(N-BMI,17 cases).The related indexes levels in each group were detected.ROC curve was drawn and analyzed.Results The levels of LDH,β2-MG,CRP and DD levels in the BMI group and LMCL group were higher than those in the N-BMI group(P＜0.05).Based on the ROC curve analysis,the optimal diagnostic cut-off points of each index in BMI were determined.The CRP and LDH had good sensitivity(100.00 ％),specificity(80.00 ％-100.00 ％) and diagnostic accuracy(80.00 ％ 100.00％).In the LMCL group,the diagnostic accuracy of DD,BXTM and β2-MG was 63.30 ％-100.00％.Conclusion The changes of LDH,CRP,β2-MG and DD in the patients with NHL are consistent with the BMI severity of lymphoma cells,which has a good clinical value in staging,curative effect judgment and prognosis.
