Minimally invasive surgery for removing intracranial hematoma and decreasing perihematomal glutamate content and permeability of blood-brain barrier
10.3969/j.issn.1671-8348.2017.18.008
- VernacularTitle:微创清除颅内血肿降低病灶周围组织谷氨酸水平及BBB通透性
- Author:
Chang LI
;
Cuie TANG
;
Rong FU
;
Likun WANG
;
Guofeng WU
- Keywords:
cerebral hemorrhage;
minimally invasive surgery for removing intracerebral hematoma;
glutamate;
blood-brain barrier;
brain water content
- From:
Chongqing Medicine
2017;46(18):2471-2474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of minimally invasive intracranial hematoma clearance on the perihematomal glutamate(Glu) level,permeability of blood-brain barrier(BBB) and brain edema.Methods Thirty rabbits with body weight of 2.80-3.40 kg were used to established the model of spontaneous intracerebral hemorrhage(ICH) and randomly divided into the minimally invasive group(MI) and control group(MC) after the model was prepared successfully.The MI group underwent minimally invasive procedures for removing intracranial hematoma by stereotactic instrument within 6 h after establishing the ICH model.The brain tissue was extracted on postoperative 1,3,7 d,and the perihematomal brain tissues were taken to detect the Glu level,BBB permeability and water content of brain tissue,which were compared with those in the control group.Results The Glu level,BBB permeability and brain water content on 1,3,7 d in the MI group were lower than those in the MC group,and the differences were statistically significant(P＜0.05).Conclusion The minimally invasive surgery for removing intracranial hematoma is helpful to reduce perihematoma Glu level,BBB permeability and brain water content.
