Research on effect of midbrain VTA dopaminergic neurons in general anesthesia

VernacularTitle:中脑腹侧被盖区多巴胺神经元在全身麻醉中的作用研究
Author: Chengxi LIU ; Dandan TAN ; Jia LI ; Yi ZHANG
Keywords: propofol; isoflurane; midbrain ventral tegmental area; dopaminergic neurons; righting reflex
From: Chongqing Medicine 2017;46(17):2320-2322
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of dopaminergic neurons of midbrain ventral tegmental area(VTA) in general anesthesia.Methods Forty adult healthy male SD rats were randomly divided into lesion group (n=20) and control group (n=20).The lesion group was given the bilateral infusion of specific dopaminergic neuron injury agent 6-OHDA in midbrain lateral VTA,while the control group received the same volume of normal saline at the same areas.The time of loss of righting reflex (LORR)loss and recovery of righting reflex(RORR)at postoperative 2 week were observed in each group.Results Compared with the control group,the LORR time in the lesion group was shortened and the RORR time was significantly prolonged under propofol-induced anesthesia (P＜0.05).However,the LORR time under the isoflurane anesthesia had no statistically significant difference between the two groups(P＞0.05),while the RORR time in the lesion group was increased(P＜0.05).Conclusion Dopaminergic neurons in midbrain VTA might play different roles in the induction and recovery of different general anesthetics.