Efficacy and safety of nebulized hypertonic saline in different concentration in infants with moderate to severe bronchiolitis
10.3760/cma.j.issn.1673-4912.2017.06.006
- VernacularTitle:雾化吸入不同浓度高渗盐水治疗中重度毛细支气管炎的疗效和安全性研究
- Author:
Jiao LU
;
Jun GU
;
Weining MA
;
Zhen LI
;
Yachun LI
;
Jianguo HONG
- Keywords:
Bronchiolitis;
Hypertonic saline;
Inhalation
- From:
Chinese Pediatric Emergency Medicine
2017;24(6):425-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of frequently nebulized hypertonic saline(HS) in different concentration with Terbutaline in infants with moderate to severe bronchiolitis.Methods A total of 195 infants were randomly enrolled to either Group A(5% HS 4ml+Terbutaline 2.5mg,n=65),Group B(3% HS 4ml + Terbutaline 2.5mg,n=65) or Group C[0.9% normal saline(NS) 4ml + Terbutaline 2.5mg,n=65].All the infants were given inhalation treatment q6h after admission for 4 times,and then q8h till the remission of wheezing.The primary outcome was the hospital length of stay(LOS),and the secondary outcomes were the clinical severity score(CSS),remission time of wheezing,cost and side effects.
