Research Progress on Pancreas Regeneration Gene Reg3
10.3870/j.issn.1004-0781.2017.07.001
- VernacularTitle:胰腺再生性基因Reg3研究进展
- Author:
Ying QIAN
;
Qianqian XU
;
Ming XIANG
- Keywords:
Regenerating gene;
Immunological regulation;
Inflammation;
Cancer
- From:
Herald of Medicine
2017;36(7):719-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective Regenerating genes express mainly in gastrointestinal tissues and the injured regenerating pancreatic tissues,which can promote the regeneration of pancreatic β cells and other tissue cells.In recent years,researches on Reg family mainly involved the gene structure of various subtypes of Reg,and its role in diabetes,gastrointestinal cancer,inflammation,anti-microbial and the related mechanisms.Among the various subtypes of Reg,regenerating geneⅢ(Reg3) plays a particularly crucial role in these diseases.Therefore,Reg3 is a promising target for the treatment of these diseases.Based on the relationships of Reg3 with a variety of diseases,our group devote to the role of Reg3 [human REG3A,and mouse Reg3γ(Reg3g)] in type 1 diabetes,inflammation-linked pancreatic carcinogenesis,and the immunological changes participated in these processes.Hence,this review will summarize serial studies on Reg3 and the feasibility of it as drug targets.
