Dosimetric comparison between three radiotherapy regimens involving supraclavicular and infraclavicular regions in breast cancer patients after breast-conserving surgery
10.3760/cma.j.issn.1004-4221.2017.07.011
- VernacularTitle:乳腺癌保乳术后全乳及锁骨上下区三种调强剂量学分析
- Author:
Huiru CHEN
;
Shi WANG
;
Zhaoxia WU
;
Xiao LI
;
Yin DUAN
;
Liang CHEN
;
Jian ZHANG
;
Xingdong GUO
;
Lin GAN
;
Cunqing YAN
;
Yue ZOU
- Keywords:
Breast neoplasms/intensity-modulated radiotherapy;
Breast neoplasms/volume modulated arc therapy;
Dosimetry
- From:
Chinese Journal of Radiation Oncology
2017;26(7):774-777
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the dosimetric difference between fixed-field static intensity-modulated radiotherapy (IMRT), fixed-field dynamic multileaf collimator (DMLC), and volumetric modulated arc therapy (VMAT), all of which involve supraclavicular and infraclavicular regions, in breast cancer patients after breast-conserving surgery.Methods This study included 14 female patients with breast cancer who received radiotherapy after breast-conserving surgery in our hospital from October 2012 to April 2016.The radiation field included the chest wall and supraclavicular and infraclavicular regions.IMRT, DMLC, and VMAT plans were generated for each patient while using identical optimization conditions.The doses to planning target volume (PTV) and organs at risk (OARs) were compared based on dose-volume histogram (DVH);one-way analysis of variance or nonparametric Wilcoxon rank test was used for comparison.Results For the dose distribution of PTV, VMAT achieved the best V95, V98, CI, and HI (P<0.009).Concerning the doses to OARs, VMAT achieved the best V5, V20, and Dmean of the ipsilateral lung and the best V5 and Dmean of the contralateral lung (P<0.022).Dmean of the spinal cord was significantly lower in VMAT than in IMRT and DMLC (P=0.004).Conclusions VMAT is preferred for the patients with breast cancer to be treated with radiotherapy involving supraclavicular and infraclavicular regions after breast-conserving surgery.It can improve the dose distribution of target and reduce the doses to organs at risk and radiotherapy toxicities.
