The Effect of Propofol on Pruritus induced by Epidural Morphine.
10.4097/kjae.1997.32.3.423
- Author:
Mi Kyeong LEE
1
;
Sang Ho LIM
;
In Ho LEE
;
Seok Min YOON
;
Young Seok CHOI
Author Information
1. Department of Anesthesiology, College of Medicine Korea University, Seoul, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Analgesics;
morphine;
Anesthetic techniques;
epidural;
Anesthetics;
intravenous;
propofol;
Complications;
pruritus
- MeSH:
Analgesics;
Anesthetics;
Humans;
Infusion Pumps;
Morphine*;
Pain, Postoperative;
Propofol*;
Pruritus*
- From:Korean Journal of Anesthesiology
1997;32(3):423-426
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Epidural morphine is used commonly for postoperative pain control. But, pruritus, although trivial, is a common side effect. It is reported that subhypnotic doses of propofol are effective against pruritus induced by epidural or subarachnoid morphine. METHODS: Sixty five patients received epidural morphine 4 mg bolus and 4 mg/day with continuous infusion for 2 days via Baxter infusor. The patients who have pruritus with scratching were allocated randomly to receive either 1 ml propofol(10 mg) or 1 ml placebo(Intralipos ) intravenously. Pruritus was assessed 5 min later using a pruritus rating scale with double-blind, placebo-controlled study. RESULTS: Forty patients showed pruritus with scratching. The overall success rate in treating pruritus was 75% in propofol group and 25% in placebo group. Compared with placebo, propofol was effective significantly(P<.05). CONCLUSIONS: These results suggest that propofol in a subhypnotic dose is an efficient drug treatment for epidural morphine induced pruritus.
