Therapeutic drug monitoring of mizoribine in renal transplant recipients
10.3969/j.issn.1001-1978.2017.07.003
- VernacularTitle:咪唑立宾治疗药物监测在肾移植术后患者中的应用进展
- Author:
Pan CHEN
;
Qian FU
;
Qiuling HUANG
;
Jun LI
;
Jie CHEN
;
Xiao CHEN
;
Changxi WANG
;
Jingjie LI
- Keywords:
mizoribine;
therapeutic drug monitoring;
renal transplantation;
pharmacokinetics;
gene polymorphism;
population pharmacokinetics;
immunosuppressor
- From:
Chinese Pharmacological Bulletin
2017;33(7):896-899
- CountryChina
- Language:Chinese
-
Abstract:
Mizoribine(MZR), as an orally prescribed immunosuppressive agent, has been applied in the prevention of rejection after kidney transplantation.MZR requires individual dosing due to the variation of bioavailability.However, therapeutic drug monitoring (TDM) of MZR is not well developed in China, as compared to other clinically used immunosuppressive agents.To our knowledge, this is the first TDM review of MZR.Pharmacokinetic characteristic, concentration determination methods and sample selection of MZR were summarized, also the rational therapeutic window was proposed.Furthermore, gene polymorphism and population pharmacokinetics of MZR were estimated.This review will provide reference for TDM-based individual dosing of MZR in renal transplant recipients.
