Application of induced pluripotent stem cells in retinal diseases
10.13389/j.cnki.rao.2017.0149
- VernacularTitle:诱导多能干细胞在视网膜疾病研究中的应用
- Author:
Songtao WANG
;
Guomin ZHOU
- Keywords:
induced pluripotent stem cell;
retinal disease;
regenerative medicine;
cell transplantation
- From:
Recent Advances in Ophthalmology
2017;37(6):587-590
- CountryChina
- Language:Chinese
-
Abstract:
Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells that can be generated from adult somatic cells.They have similar characteristics and function to embryonic stem cells (ESCs).Over the past decade,iPSCs were widely concerned in regenerative medicine and stem cell field.Especially the patient specific iPSCs have several advantages over ESCs,such as convenient source,do not exist immune rejection and ethical issues,even keep certain individual genotype.At present,tremendous progress have been made about the application of iPSCs in a variety of retinal diseases.Here,this article reviews pluripotent stem cell sources of RPE,photoreceptors and retinal ganglion cells and current transplantation strategies,the safety problems and prospects.
