Research progress in myocardial fibrosis regulated by microRNAs and their pathways
10.3760/cma.j.issn.2095-4255.2017.06.020
- VernacularTitle:调控心肌纤维化的主要微小核糖核酸及其通路研究进展
- Author:
Juanniu ZHANG
;
Tao JI
;
Shuqiu SUN
- Keywords:
Myocardial fibrosis;
MicroRNAs;
Gene regulation
- From:
Chinese Journal of Endemiology
2017;36(6):464-468
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial fibrosis is a pathological process characterized by fibroblast proliferation and collagen deposition,which occurs in the normal structure of the myocardium.MicroRNAs (miRNAs) are a class of endogenous,non-coding RNA of approximately 22 nucleotides in length,regulating gene expression at posttranscriptional level by complementary pairing with the target gene mRNA.Recent studies have showed that miRNAs play an important role in the formation of myocardial fibrosis,therefore,much attention has been paid to miRNAs as they may serve as targets for prevention and treatment of myocardial fibrosis.
