Structures and functions of tripartite-motif proteins
10.3760/cma.j.issn.0254-5101.2017.06.013
- VernacularTitle:三结构域蛋白(TRIM)家族结构及功能的研究进展
- Author:
Yanqing CHEN
;
Shuhui CAO
;
Chuanyou LI
- Keywords:
TRIM protein family;
Structure;
Function
- From:
Chinese Journal of Microbiology and Immunology
2017;37(6):479-484
- CountryChina
- Language:Chinese
-
Abstract:
Members of the tripartite-motif (TRIM) protein family share a highly conserved domain architecture known as RBCC motif,which is composed of a RING finger domain,one or two B-box domains,a coiled-coil domain as well as diverse types of C-terminal regions.TRIM proteins can not only maintain the normal physiological functions of the body,but also regulate the development of various diseases.In the current review,we focus on recent advances in the structures of TRIM proteins and their functions in the development of viral infection,cancer and neurodegenerative disease.
