Changes of serum UHRF1 levels in perioperative patients with esophageal squamous cell carcinoma
10.13602/j.cnki.jcls.2017.05.05
- VernacularTitle:围手术期食管鳞状细胞癌患者血清UHRF1水平变化
- Author:
Jinchang LI
;
Lili YU
;
Jun WU
;
Feng YAN
- Keywords:
esophageal squamous cell carcinoma;
ubiquitin-like with PHD and ring finger domains 1;
dynamic monitoring
- From:
Chinese Journal of Clinical Laboratory Science
2017;35(5):338-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect serum ubiquitin-like with PHD and ring finger domains 1 (UHRF1) levels in the patients with esophageal squamous cell carcinoma (ESCC),and analyze their differences among different clinicopathological features subgroups and changes during the perioperative period.Methods Serum samples from 130 preoperative ESCC patients,62 patients 1 week after operation,14 patients 1 week and 2 weeks after operation and 67 healthy controls,and clinicopathological data from ESCC patients were collected.Serum UHRF1 levels were detected by ELISA,and the differences among different groups were analyzed with independent t test,paired t test or one-way ANOVA.Results Serum UHRF1 levels in 130 preoperative ESCC patients were significantly higher than that in healthy controls (t =7.680,P ＜ 0.01),and they were related to the ESCC patients' tumor size,differentiation degree,tumor invasion,lymph nodes metastasis and pTNM stage (P ＜ 0.05),but unrelated to the patients' age,gender,tumor location and types (P ＞ 0.05).Serum UHRF1 levels in 62 postoperative patients were significantly lower than that before operation (t =5.530,P ＜ 0.01),but similar to that in healthy controls (t =1.622,P ＞ 0.05).The serum UHRF1 levels before operation,1 week after operation and 2 weeks after operation in 14 ESCC patients decreased gradually (F =7.595,P ＜ 0.01).Conclusion Serum UHRF1 levels may be a potential biomarker for dynamically monitoring perioperative ESCC patients.
