Correlation of IL-17 gene polymorphism with chronic obstructive pulmonary disease in Xinjiang aera
10.13602/j.cnki.jcls.2017.05.06
- VernacularTitle:IL-17基因多态性位点与新疆地区慢性阻塞性肺病的风险关系
- Author:
Dan XU
;
Fengsen LI
;
Li GONG
;
Zheng LI
;
Jing JING
;
Jing WANG
- Keywords:
chronic obstructive pulmonary disease;
IL-17;
genetic polymorphism
- From:
Chinese Journal of Clinical Laboratory Science
2017;35(5):341-345
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of IL-17 gene polymorphism with chronic obstructive pulmonary diseases (COPD) in Xinjiang area.Methods Five single nucleotide polymorphism (SNP) loci of IL-17A gene,including rs2275913,rs3819024,rs3819025,rs4711998 and rs8193036,and 4 SNP loci of IL-17F gene such as rs12203582,rs1266828,rs7771466 and rs9382084 from 149 COPD patients and 97 healthy controls were performed typing using the multiple single-base extension SNP (SNaPshot) technology,and the risk correlations of different genotypes and alleles of these loci with COPD were analyzed.Results There was no difference in the SNP of 5 IL-17A gene loci and 4 IL-17A gene loci between stable COPD patients and healthy controls,and the mutation and genotype distribution of these loci were not correlated with COPD susceptibility.However,the linkage disequilibrium analysis showed that there was significant difference in the distribution of IL-17A gene haplotype CAA between COPD patients and healthy controls (OR =0.244,95％ CI:0.057-1.043,P ＜ 0.05).Conclusion The IL-17F and IL-17A gene polymorphisms are not correlated with the risk of COPD,but the haplotype CAA of 1L-17A gene may be related to the susceptibility of COPD in Xinjiang area.
