Correlations between HIV-1 subtypes and changes in CD4+T cell count over time
10.3760/cma.j.issn.0254-5101.2017.06.010
- VernacularTitle:HIV-1亚型与CD4+T淋巴细胞计数自然变化趋势的相关性分析
- Author:
Kun FANG
;
Xiaoshan LI
;
You GE
;
Yu JI
;
Yue SONG
;
Guoping DU
;
Wenjuan YAN
;
Pingmin WEI
- Keywords:
HIV-1;
Subtype;
CD4+T lymphocyte;
Correlation analysis
- From:
Chinese Journal of Microbiology and Immunology
2017;37(6):461-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the correlations between HIV-1 subtypes and changes in CD4+T cell count over time in patients with different subtypes of HIV-1 infection.Methods A total of 94 patients who were diagnosed with HIV-1 infection in Nanjing and received at least twice CD4+T cell counting test before antiretroviral therapy (ART) were recruited in this study.Descriptive analysis was used to present the rates of CD4+T cell decline for different HIV-1 subtypes.Logistic regression analysis and nonparametric test were conducted to investigate the factors responsible for CD4+T cell decline and to analyze the correlations between the rates of CD4+T cell decline and HIV-1 subtypes.Results The median monthly rate of CD4+T cell decline was-2.20 [interquartile range (IQR):-11.36-2.13] cell/μl.Of all patients,25.5% (24/94) had a significant decline (≥30%) in CD4+T cell count.Compared with the patients infected with CRF01_AE,those infected with CRF07_BC (OR=0.28,95%CI: 1.7-6.5) or other subtypes (OR=0.16,95%CI: 1.0-2.9) had a lower risk of significant decline in CD4+T cell count.In addition,results of the nonparametric test showed that the patients infected with CRF01_AE (M=-21.54,IQR:-30.97——11.92 cell/μl) had a faster CD4+T cell loss than those infected with CRF07_BC (M=-11.26,IQR:-14.06——5.63 cell/μl) (P=0.033).Conclusion HIV-1 subtype is associated with the rate of CD4+T cell decline.It is important to monitor the changes in CD4+T cell count in patients infected with CRF01_AE and to carry out timely ART.
