Antibodies and vaccines against glycoprotein of Marburg virus
10.3760/cma.j.issn.0254-5101.2017.06.011
- VernacularTitle:马尔堡病毒G蛋白相关抗体和疫苗的研究进展
- Author:
Li ZHANG
;
Qianqian LI
;
Weijin HUANG
;
Youchun WANG
- Keywords:
Marburg virus;
Glycoprotein;
Protein structure;
Protective antibody;
Vaccine
- From:
Chinese Journal of Microbiology and Immunology
2017;37(6):467-473
- CountryChina
- Language:Chinese
-
Abstract:
Marburg virus (MARV) is a lethal virus that causes fatal hemorrhagic fever.It belongs to the Filoviridae family which also includes Ebola virus.MARV is similar to Ebola virus in structure and infection mechanism.Moreover,the diseases caused by them have similar clinical symptoms.However,researches on MARV are less than those on Ebola virus.In this review,we focus on the viral structure,especially the structure of MARV glycoprotein (GP) which determines its infectivity,functions of MARV GP as well as protective antibodies and vaccines against this protein.
