Progress in research of the DrrAB efflux system of Streptomyces peucetius
10.3969/j.issn.1002-2694.2017.05.013
- VernacularTitle:链霉菌DrrAB外排系统的研究进展
- Author:
Zhenyue FENG
;
Defu LIU
;
Shuo LIU
;
Lizi WANG
;
Yudong CUI
- Keywords:
Streptomyces peucetius;
antibiotics;
DrrAB efflux system
- From:
Chinese Journal of Zoonoses
2017;33(5):454-458
- CountryChina
- Language:Chinese
-
Abstract:
The bacterium Streptomyces peucetius produces doxorubicin and daunorubicin,and the two widely used anticancer antibiotics.Two open reading frames,drrA and drrB,were proposed to encode for an ABC (ATP-binding cassette) type of permease that carries out export of the antibiotic ABC (ATP binding cassette)-type transporter for the exportation of these two antibiotics.In this paper,the structure,expression and interaction of DrrA and DrrB protein and the research progress of the assembly and multi drug efflux function of DrrAB are briefly reviewed.
