The expressions of aerobic glycolytic enzymes in the cerebellums of patients with autism
10.3969/j.issn.1002-0152.2017.05.006
- VernacularTitle:孤独症患者小脑中有氧糖酵解酶的表达
- Author:
Peipei CHENG
;
Shunying YU
- Keywords:
Autism;
Cerebellum;
Aerobic glycolysis;
Pyruvate dehydrogenase
- From:
Chinese Journal of Nervous and Mental Diseases
2017;43(5):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression levels of aerobic glycolytic enzymes in the cerebellums and its correlation with pathogenesis of autism in patients with autism. Methods The Western blotting was used to quantita-tively examine the expression levels of aerobic glycolytic enzymes, including HK-Ⅰ, HK-Ⅱ, PFKP, PKM1/2, PKM2, GAPDH, PDH and LDHA in the cerebellums of eight patients with autism and eight age-matched controls. Results Compared to controls, PDH expression was significantly decreased [(0.715±0.342) vs.(1.028±0.203), P=0.043], while expression of other seven aerobic glycolytic enzymes remained unchanged ( P>0 . 05 ) in the cerebellums of patients with autism. Conclusion The present study has revealed a decrease in the expression of PDH in the cerebellums of patients with autism, which may be involved in the pathologic process of autism.
