Therapeutic Effect of Chinese Herbal Medicine Compound for Recurrent Genital Herpes and Its Effect on Serum Th17/Treg Cells
10.13359/j.cnki.gzxbtcm.2017.04.010
- VernacularTitle:中药复方治疗复发性生殖器疱疹的临床观察及对血清Th17/Treg细胞的影响
- Author:
Mengyi LIAO
;
Min HE
;
Daoshun SUI
;
Fengyan FANG
- Keywords:
recurrent genital herpes;
Th17 cells;
Treg cells;
clearing heat and removing dampness;
tonifying Qi and blood
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2017;34(4):510-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of heat-clearing, dampness-removing, and Qi-blood-tonifying Chinese herbal medicine compound for the treatment of recurrent genital herpes(RGH), and to investigate the expression levels of Th17 cells and Treg cells in peripheral blood of patients with RGH as well as their role in the pathogenesis of RGH. Methods Sixty RGH patients were randomly divided into experimental group and control group, 30 cases in each group. The experimental group was treated with Chinese medicine decoction, and the control group was treated with Aciclovir tablets orally. The treatment course covered 6 months. The percentages of Th17 cells and Treg cells in the peripheral blood of the RGH patients were detected with flow cytometry. Results (1) After treatment for 3, 6 months, the total effective rate of the experimental group was 53.33%, 80.00%, and that of the control group was 23.33%, 46.67% respectively. There were significant difference between the two groups(P < 0.05).(2) After treatment, the percentage of Th17 cells and the ratio ofTh17/Treg cells were decreased while the percentage of Treg cells was increased in the two groups, and the differences before and after treatment were significant in the experimental group(P<0.05) while were insignificant in the control group (P > 0.05). The inter-group comparison showed the decrease of Th17 cell percentage and Th17/Treg cell ratio as well as the increase of Treg cell percentage in the experimental group was superior to that in the control group, the differences being significant (P<0.05). Conclusion The curative effect of Chinese herbal compound for RGH is better than that of the control group. Chinese herbal medicine compound can decrease the level of Th17 cells, increase the level of Treg cells, thus to decrease the ratio of Th17/Treg cells, indicating that heat-clearing, dampness-removing, and Qi-blood-tonifying Chinese herbal medicine compound can correct the imbalance of Th17/Treg cells, and then plays a role in anti-inflammation and immune regulation.
