Meta-Analysis of Chinese Medicine Combined with Chemotherapy in Preventing StageⅡ-ⅢColorectal Cancer Patients from Postoperative Recurrence and Metastasis
10.13359/j.cnki.gzxbtcm.2017.04.034
- VernacularTitle:中医药联合化疗预防Ⅱ~Ⅲ期结直肠癌术后复发转移的Meta分析
- Author:
Kaibo GUO
;
Qingying YAN
;
Shanming RUAN
;
Yingying WANG
;
Minhe SHEN
- Keywords:
colorectal cancer;
stageⅡ-Ⅲ;
postoperative recurrence and metastasis;
Chinese medicine combined with chemotherapy;
Meta-analysis
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2017;34(4):617-622
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the effectiveness of Chinese medicine(CM) combined with chemotherapy in preventing stageⅡ-Ⅲ colorectal cancer patients from postoperative recurrence and metastasis. Methods Databases of PubMed, EMBase, Cochrane Library, China National Knowledge Information(CNKI), VIP Database, Wanfang Database, and SinoMed were retrieved to collect randomized controlled trials(RCTs) of CM combined with chemotherapy in preventing stageⅡ-Ⅲ colorectal cancer patients from postoperative recurrence and metastasis. And then the quality of the included RCTs was evaluated systematically. Results Seven RCTs involving 700 cases of stageⅡ-Ⅲ colorectal cancer patients were included, 355 patients in treatment group were treated with CM combined with chemotherapy, and 345 patients in control group were treated with chemotherapy alone. The results of Meta-analysis showed that treatment group was superior to the control group in preventing the recurrence and metastasis of colorectal cancer one , 2 and 3 year(s) after the radical surgery, showing statistically significant differences(P < 0.05), while the difference of five-year recurrence and metastasis rate was not statistically significant between the two groups(P > 0.05). At the same time, CM combined with chemotherapy had better effect than chemotherapy alone on prolonging the time for recurrence and metastasis, improving performance status and relieving the symptoms, the difference being significant(P<0.05). Conclusion CM combined with chemotherapy exerts better effect than chemotherapy alone in preventing stageⅡ-Ⅲ colorectal cancer patients from postoperative recurrence and metastasis and onimproving the quality of life of the patients. However, for the low methodological quality of the included trials, the conclusion still needs more large-size sample, multiple-center, and high-quality clinical trials to be confirmed.
